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Evidence-based hCG answers
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hCG Curve: Multi-Draw Trend

Three or more values, one fitted curve — because a trend line answers questions two points can't.

YOUR SERIAL VALUES
HOW THE FIT WORKS

Early hCG changes exponentially, so the values are plotted on a logarithmic scale, where exponential growth becomes a straight line. The tool fits that line by least squares across all your draws and reports the overall doubling time (or half-life, if falling), the equivalent 48-hour change, and how consistently your points follow one trend (R²). A high R² means one steady process; scattered points can reflect different laboratories or assays — always trend values from the same lab when possible.

The fitted 48-hour change is interpreted against the same thresholds as the two-value calculator: Barnhart 2016 level-stratified minimums, the 35% floor, and NICE NG126. One honest caution: a single fitted line assumes one ongoing process. If your values rose and then fell, the last two points matter more than the average — the tool will tell you when that applies.

KEY SOURCES
1. Barnhart KT, Guo W, Cary MS, et al. Differences in serum human chorionic gonadotropin rise in early pregnancy by race and value at presentation. Obstet Gynecol. 2016;128(3):504-511.
2. Seeber BE, Sammel MD, Guo W, Zhou L, Hummel A, Barnhart KT. Application of redefined human chorionic gonadotropin curves for the diagnosis of women at risk for ectopic pregnancy. Fertil Steril. 2006;86(2):454-459.
3. National Institute for Health and Care Excellence. Ectopic pregnancy and miscarriage: diagnosis and initial management. NICE guideline NG126. 2019 (updated 2023).
4. Butts SF, Guo W, Cary MS, et al. Predicting the decline in human chorionic gonadotropin in a resolving pregnancy of unknown location. Obstet Gynecol. 2013;122(2 Pt 1):337-343.
Two values? Use the main calculator →